An exceptionally useful tool in the development of novel chiral catalysts for carbonyl chemistry is the activation of carbonyl groups by double hydrogen bonding (see scheme). A diverse set of reactions such as the asymmetric Diels-Alder, hetero-Diels-Alder, aldol, and Morita-Baylis-Hillman reactions can be accelerated by such double-hydrogen-bonding catalysts.
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CITATION STYLE
Pihko, P. M. (2004, April 13). Activation of carbonyl compounds by double hydrogen bonding: An emerging tool in asymmetric catalysis. Angewandte Chemie - International Edition. https://doi.org/10.1002/anie.200301732