The recently discovered apolipoprotein A5 (APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and -1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively (P C variations in the APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in -1131C carriers than in -1131T subjects of the control group and that high-density-lipoprotein cholesterol was decreased in -1131C carriers among CHD patients. © 2005 Published by Elsevier Inc.
CITATION STYLE
Liu, H., Zhang, S., Lin, J., Li, H., Huang, A., Xiao, C., … Huang, D. (2005). Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese. Metabolism: Clinical and Experimental, 54(5), 568–572. https://doi.org/10.1016/j.metabol.2004.11.009
Mendeley helps you to discover research relevant for your work.