Asymmetric allylation of aromatic aldehydes catalyzed by chiral phosphoramides prepared from (S)-proline

Abstract

Chiral phosphoramides prepared from (S)-proline were used to catalyze the allylation and crotylation of aromatic aldehydes with allylic trichlorosilanes in good enantioselective yields. Phosphoramides 44 and 4m gave chiral homoallylic alcohols and their enantiomers, respectively, with similar levels of enantioselectivity.