Chemotherapy of advanced breast cancer: A controlled randomized trial of cyclophosphamide versus a four-drug combination

Abstract

Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but the differences between the two treatments did not achieve formal significance. The combination was logistically easier to manage and produced less toxicity. © 1975, Cancer Research Campaign. All rights reserved.