Abstract
Since the discovery of toll-like receptors (TLRs) in-Dro-sophila in 1996 [1], scientific knowledge has exploded on the role of pattern recognition receptors in immunity, host defense, and in various noninfectious conditions including liver diseases. Studies demonstrated that TLR expression in immune and nonimmune cells plays an important role in tissue homeostasis, response to infections, and injury in the liver. Links between TLR activation and modulation of functions of TLRs in liver diseases are being discovered. Here, we discuss the characteristics and signaling pathways of TLRs and summarize current knowledge on their role in liver diseases. © 2010 Springer-Verlag Berlin Heidelberg.
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CITATION STYLE
Szabo, G., & Mandrekar, P. (2010). Toll-like receptors. In Signaling Pathways in Liver Diseases (pp. 149–159). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_9
