2,6-Dicarboxypyridinium chlorochromate. An efficient and selective reagent for the mild deprotection of acetals, thioacetals, and 1,1-diacetates to carbonyl compounds

Abstract

2,6-Dicarboxypyridinium chlorochromate (2,6-DCPCC) was found to be an efficient reagent for the conversion of acetals, thioacetals, and 1,1-diacetates to their corresponding carbonyl compounds under neutral and anhydrous conditions in good to excellent yields. Selective deprotection of acetals or 1,1-diacetates in the presence of thioacetals at room temperature is also observed with this reagent. © Springer-Verlag 2004.