Abstract
Chiral diphosphite ligands L1-L3 were prepared by the reaction of (1S,5S,6R)-(cis,trans)-spiro[4.4]nonane-1,6-diol with chlorophosphites. These ligands were tested in the rhodium catalyzed hydroformylation of styrene and enantioselectivities up to 69% were achieved. High regioselectivities (97%) to 2-phenylpropanal and high yields (98%) were obtained under mild reaction conditions. The influence of reaction conditions is also discussed.
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CITATION STYLE
Jiang, Y., Xue, S., Li, Z., Deng, J., Mi, A., & Chan, A. S. C. (1998). Asymmetric synthesis. Part 29: Asymmetric hydroformylation of styrene catalyzed by chiral spiro diphosphite-rhodium(I) complexes. Tetrahedron Asymmetry, 9(18), 3185–3189. https://doi.org/10.1016/S0957-4166(98)00339-5
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