Cesium hydroxide catalyzed addition of alcohols and amine derivatives to alkynes and styrene

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Abstract

In the presence of catalytic amounts of cesium hydroxide (CsOH · H2O), alcohols, substituted anilines and heterocyclic amines undergo an addition in NMP to phenylacetylene leading to functionalized enol ethers and enamines. Anilines add to styrene (90-120°C, 12-14 h) leading to N-substituted anilines in satisfactory yields.

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APA

Tzalis, D., Koradin, C., & Knochel, P. (1999). Cesium hydroxide catalyzed addition of alcohols and amine derivatives to alkynes and styrene. Tetrahedron Letters, 40(34), 6193–6195. https://doi.org/10.1016/S0040-4039(99)01133-8

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