Abstract
Background: Variation in the Fat-Mass and Obesity-Associated (FTO) gene has been associated with obesity, diabetes, and hypertension. However, its association with cardiovascular disease (CVD) in healthy populations and any interaction with physical activity remain unclear. Methods: The FTO rs8050136 allele was determined in a prospective cohort study of 21,674 apparently healthy White US women in the Women's Genome Health Study. Results: During a mean follow-up of 12.7 ± 2.0 years, 664 incident CVD events occurred. The risk allele (A) was associated with higher prevalence of hypertension, diabetes, and metabolic syndrome (all P
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Ahmad, T., Chasman, D. I., Mora, S., Paré, G., Cook, N. R., Buring, J. E., … Lee, I. M. (2010). The Fat-Mass and Obesity-Associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women. American Heart Journal, 160(6), 1163–1169. https://doi.org/10.1016/j.ahj.2010.08.002
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