Genome-wide association study identifies common variants associated with circulating vitamin E levels

  • J.M. M
  • K. Y
  • W. W
  • et al.
ISSN: 0964-6906
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Abstract

In genome-wide association studies (GWAS) of common genetic variants associated with circulating alphaand gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P = 1.7 null 10-8) and rs11057830 on 12q24.31 (P = 2.0 null 10-8) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P = 2.7 null 10-10). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P = 7.8 null 10-12 (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P = 1.4 null 10-10 (rs2108622 on 19pter-p13.11 near CYP4F2) and P = 8.2 null 10-9 (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n = 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P < 1 null 10-4 identified. Published by Oxford University Press 2011.

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APA

J.M., M., K., Y., W., W., H., Z., M.C., C., M.E., W., … D., A. (2011). Genome-wide association study identifies common variants associated with circulating vitamin E levels. Human Molecular Genetics, 20(19), 3876–3883. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L362553236

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