Vinylogous Mannich reactions. Catalytic, asymmetric additions of triisopropylsilyloxyfurans to aldimines

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Abstract

The vinylogous Mannich reaction of triisopropylsilyloxyfurans with aldimines in the presence of catalytic amounts of the Ti(O(i)Pr)4/(S)-BINOL complex gave substituted aminoalkyl butenolides in good yield and enantioselectivities (up to 54% ee).

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APA

Martin, S. F., & Lopez, O. D. (1999). Vinylogous Mannich reactions. Catalytic, asymmetric additions of triisopropylsilyloxyfurans to aldimines. Tetrahedron Letters, 40(51), 8949–8953. https://doi.org/10.1016/S0040-4039(99)01939-5

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