In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

N/ACitations
Citations of this article
70Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Oral administration is the most common route for drug administration. However, after oral administration, the absorption may be erratic and incomplete. P-glycoprotein, an efflux transporter localized in the enterocyte, limits the absorption of transported drugs extruding them back to the intestinal tract. The interaction between new drug candidates and P-glycoprotein is investigated in vitro during early stages of drug development. However, it is uncertain how well the in vitro studies actually predict the in vivo P-glycoprotein effect on the extent of oral absorption, since the in vitro and in vivo correlation has not been achieved. In the present review, the recent approaches to compare the in vitro and in vivo data are described and parameters are proposed that could be adequate for a reliable in vitro and in vivo correlation of P-glycoprotein contribution on intestinal absorption. The present article identifies an evident lack of suitable in vivo data. A significant in vitro and in vivo correlation would increase the value of in vitro studies and could reduce costs during the process of drug development. © 2008 Elsevier B.V. All rights reserved.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

del Amo, E. M., Heikkinen, A. T., & Mönkkönen, J. (2009, February 15). In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption. European Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.ejps.2008.11.005

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 33

60%

Researcher 13

24%

Professor / Associate Prof. 9

16%

Readers' Discipline

Tooltip

Medicine and Dentistry 20

38%

Agricultural and Biological Sciences 17

32%

Pharmacology, Toxicology and Pharmaceut... 11

21%

Chemistry 5

9%

Save time finding and organizing research with Mendeley

Sign up for free