GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

N/ACitations
Citations of this article
804Readers
Mendeley users who have this article in their library.

Abstract

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R2≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., … Koellinger, P. D. (2013). GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science, 340(6139), 1467–1471. https://doi.org/10.1126/science.1235488

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 290

52%

Researcher 152

27%

Professor / Associate Prof. 101

18%

Lecturer / Post doc 15

3%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 172

42%

Biochemistry, Genetics and Molecular Bi... 95

23%

Medicine and Dentistry 73

18%

Psychology 73

18%

Article Metrics

Tooltip
Mentions
Blog Mentions: 10
News Mentions: 14
References: 3
Social Media
Shares, Likes & Comments: 134

Save time finding and organizing research with Mendeley

Sign up for free