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Design of a flow-through polarographic sensor based on metal films for determining N-nitrosodiethanolamine levels in rabbit biological fluids

Sensors (2006) 6(11) 1555-1567
DOI: 10.3390/s6111555
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Abstract

The construction and characterization of a flow-through polarographic detector for catalyzing the electroreduction of N-nitrosodiethanolamine (NDELA), is discussed. The flow-through cell is equipped with a gold wire electrode (a thin mercury film deposited on a gold substance). The response is evaluated with respect to substance diameter, length, concentration of modifying film, operating potential, supporting electrolyte and pH, and flow rate in the DC mode. The system allows the determination of N-nitrosodiethanolamine in rabbit biological fluids with relatively inexpensive equipment. © 2006 by MDPI.

Figures

  • Figure 1. Scanning Electron Micrographs (at 8 kV) of Hg and Pb particle distribution on the different deposit surfaces: (a) Hg (4mM/gold), (b) Hg (4mM/GCE), (c) Hg (4mM/CFE), (d) Pb (6 mM)/GCE.
  • Figure 2. Atomic force microscopy images of a mercury (2 mM)/gold film.
  • Figure 3. Atomic force microscopy images of a lead (6 mM)/glassy carbon film.
  • Figure 4. Differential pulse voltammograms of NDELA (16 mg/l) for different modified electrodes in LiClO4: (a) Pb (4 mM)/GCE; and (b) Hg (4 mM)/Au, Scan rate 10 mV/s; pulse height 50 mV.
  • Figure 5. Cyclic voltammogram of NDELA (1 × 10–3 M) on an Hg/Au electrode in Britton-Robinson buffer (pH 6.19) at a scan rate of 25 mV/s.
  • Figure 6. (a) Magnitude of the peak current, ip, as a function of the square root of the scan rate for NDELA reduction, and (b) peak potentials as a function of the logarithm of the scan rates for NDELA reduction.
  • Figure 7. DPV obtained to produce a calibration plot for NDELA at a Hg (4 mM)/Au. The current peak value was at −1.32 V (1) with 8 mg/l of NDELA, (2) with 16 mg/l of NDELA, (3) with 32 mg/l of NDELA, and (4) with 64 mg/l of NDELA. Deposition time, 240 sec; scan rate, 10 mV/s; pulse height, 50 mV.
  • Figure 8. Hydrodynamic voltammogram obtained for NDELA (20 µg) using an Hg/Au detector. Stationary phase, Phenomenex Luna CN column (particle size, 5 µm; 250 mm × 4.6 mm i.d.); Mobile phase, methanol:water (10:90, v/v) containing 0.2 mM lithium perchlorate; flow rate, 0.3 ml/ min.

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CITATION STYLE

APA

Wang, L. H., Hsia, H. C., & Lan, Y. Z. (2006). Design of a flow-through polarographic sensor based on metal films for determining N-nitrosodiethanolamine levels in rabbit biological fluids. Sensors, 6(11), 1555–1567. https://doi.org/10.3390/s6111555

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