Abstract
A continuous flow centrifuge designed for the perfusion of lab scale bioreactors has been evaluated for the cultivation of Chinese Hamster Ovary (CHO) cells in a 2 L stirred tank reactor. Good separation efficiency was attained. The applied bowl speeds and medium recirculation rates did not affect cell growth or viability. Unlike cross flow filtration techniques, no product retention occurred during the process.
Cite
CITATION STYLE
Chatzisavido, N., Björling, T., Fenge, C., Boork, S., Lindner-Olsson, E., & Apelman, S. (1994). A Continuous Cell Centrifuge for Lab Scale Perfusion Processes of Mammalian Cells. In Animal Cell Technology: Basic & Applied Aspects (pp. 463–468). Springer Netherlands. https://doi.org/10.1007/978-94-011-0848-5_70
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