Molecular mechanism by which Us3 protein kinase regulates the pathogenicity of herpes simplex virus type-1

Abstract

Herpes simplex virus type-1 (HSV-1) causes a range of human diseases, from mild uncomplicated mucocutaneous infection to life-threatening ones. The Us3 gene of HSV-1 encodes a serine/threonine protein kinase that is highly conserved among alphaherpesviruses. Accumulating evidence suggests that Us3 is a critical regulator of HSV-1 infection; however, the molecular mechanism by which Us3 regulates HSV-1 pathogenicity remains to be elucidated. This article presents a brief summary of the present knowledge on the roles of HSV-1 Us3, with a special focus on its relevancy in vivo.