Central nervous system (CNS) involvement in multiple myeloma (MM) is a rare and challenging complication associated with poor prognosis and limited treatment options. Emerging T-cell directing therapies, such as bispecific antibodies (bsAbs) and chimeric antigen receptor T cells (CAR-T), have shown remarkable success in treating MM, but their efficacy in CNS involvement remains unclear. Elranatamab, a humanized bispecific antibody targeting B-cell maturation antigen (BCMA) and CD3-expressing T cells, has demonstrated promising results in relapsed refractory MM. However, its efficacy in treating CNS-MM has not been reported. We present a case of a 37-year-old male MM patient with CNS involvement who has been successfully treated with Elranatamab.
CITATION STYLE
Mutlu, Y. G., Yıgıt Kaya, S., Maral, S., Melek, E., Baslar, Z., Kaynar, L., & Sevindik, O. G. (2023). Relapsed refractory multiple myeloma with CNS involvement successfully treated with Elranatamab: first reported case. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1276295
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