Multifocal choroiditis and panuveitis

Abstract

Multifocal choroiditis with panuveitis (MCP) was first described in 1973 as a distinctive ophthalmoscopic appearance that resembles ocular histoplasmosis syndrome (OHS). The first series of patients was reported in 1984 with lesions primarily at the level of RPE and inner choroid associated with vitreous cells, and it was named multifocal choroiditis with panuveitis. The cause of this entity is unknown. Multifocal choroiditis with panuveitis is an uncommon, chronic, recurrent disease, which affects females more than males by a ratio of 3:1 or greater. It has been reported in children from the age of 6 to adults aged 69, but is more common in the third and fourth decades. It is more common in myopes and, in approximately 80 % of cases, is bilateral, although commonly presents asymmetrically, and the second eyes are often asymptomatic. Recurrent bouts of inflammation occur unilaterally or bilaterally, separately or simultaneously, and often occur around the sites of previous inflammation.