This chapter describes a method for the measurement of free gadolinium in nanoparticle samples. Conjugation of a gadolinium-chelate to a nanoparticle allows the particle’s distribution to be imaged via magnetic resonance imaging (MRI). Free (unchelated) gadolinium is a known toxin, being a heavy metal, and may contribute towards total gadolinium concentration. Determining the amount of free gadolinium is therefore an important aspect of the preclinical characterization of gadolinium-chelate MRI imaging agent nanoparticles.
CITATION STYLE
Clogston, J. D., & Patri, A. K. (2011). Detecting and Measuring Free Gadolinium in Nanoparticles for MRI Imaging. In Methods in Molecular Biology (Vol. 697, pp. 101–108). Humana Press Inc. https://doi.org/10.1007/978-1-60327-198-1_10
Mendeley helps you to discover research relevant for your work.