We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation. © 2008 Springer Science+Business Media, LLC.
CITATION STYLE
Chernov, M., Putnam, R. W., & Leiter, J. C. (2008). A computer model of mammalian central Co2 chemoreception. In Advances in Experimental Medicine and Biology (Vol. 605, pp. 301–305). https://doi.org/10.1007/978-0-387-73693-8_52
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