Calcium desensitization mechanism and treatment for vascular hyporesponsiveness after shock

Abstract

Shock, the common pathological process of many critical illnesses, is often accompanied by vascular hyporeactivity, which severely interferes with the development and treatment of shock and other critical conditions, especially interferes with the application of vasoactive agents. So, it is very important to shed light on the mechanisms and search for the effective measures. Lots of studies focused on the characteristics of vascular hyporeactivity and mechanisms following shock in recent years. Since the limitation of previous mechanisms for vascular hyporesponsiveness (receptor desensitization mechanism and membrane hyperpolarization mechanism), our research group raised calcium desensitization mechanism for vascular hyporesponsiveness after shock and proposed pertinent treatment measures.