Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a number of diseases. Amongst the MMP members, MMP−9 has generated considerable attention because of its possible involvement in inflammatory responses, blood-brain barrier permeability, the regulation of perineuronal nets, demyelination, and synaptic long-term potentiation. Emerging evidence indicate an association between MMP−9 and the syndrome of depression. This review provides an updated and comprehensive summary of the probable roles of MMP−9 in depression with an emphasis on the mechanisms and potential of MMP−9 as a biomarker of depression.
CITATION STYLE
Li, H., Sheng, Z., Khan, S., Zhang, R., Liu, Y., Zhang, Y., … Xue, M. (2022, March 18). Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression. Frontiers in Neurology. Frontiers Media S.A. https://doi.org/10.3389/fneur.2022.861843
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