Abstract
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily. © 1993 Nature Publishing Group.
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CITATION STYLE
Kubo, Y., Baldwin, T. J., Nung Jan, Y., & Jan, L. Y. (1993). Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature, 362(6416), 127–133. https://doi.org/10.1038/362127a0
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