The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis

12Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes. The response and/or adaptation to hypoxia and other changing environmental conditions can influence the properties and functions of membranes by modifying lipid composition. In the yeast Kluyveromyces lactis, the KlMga2 gene is a hypoxic regulatory factor for lipid biosynthesis-fatty acids and sterols- A nd is also involved in glucose signaling, glucose catabolism and is generally important for cellular fitness. In this work we show that, in addition to the above defects, the absence of the KlMGA2 gene caused increased resistance to oxidative stress and extended lifespan of the yeast, associated with increased expression levels of catalase and SOD genes. We propose that KlMga2 might also act as a mediator of the oxidative stress response/adaptation, thus revealing connections among hypoxia, glucose signaling, fatty acid biosynthesis and ROS metabolism in K. lactis.

References Powered by Scopus

Nile red: A selective fluorescent stain for intracellular lipid droplets

2089Citations
N/AReaders
Get full text

Molecular evidence for an ancient duplication of the entire yeast genome

1468Citations
N/AReaders
Get full text

Oxygen stress: A regulator of apoptosis in yeast

897Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Stress tolerance phenotype of industrial yeast: industrial cases, cellular changes, and improvement strategies

32Citations
N/AReaders
Get full text

Phenotypic suppression caused by resonance with light-dark cycles indicates the presence of a 24-hours oscillator in yeast and suggests a new role of intrinsically disordered protein regions as internal mediators

6Citations
N/AReaders
Get full text

The small GTPase KlRho5 responds to oxidative stress and affects cytokinesis

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Santomartino, R., Camponeschi, I., Polo, G., Immesi, A., Rinaldi, T., Mazzoni, C., … Bianchi, M. M. (2019). The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis. FEMS Yeast Research, 19(3). https://doi.org/10.1093/femsyr/foz020

Readers over time

‘19‘20‘21‘22‘23‘2400.751.52.253

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

67%

Professor / Associate Prof. 1

17%

Researcher 1

17%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 5

71%

Agricultural and Biological Sciences 1

14%

Computer Science 1

14%

Save time finding and organizing research with Mendeley

Sign up for free
0