Abstract: KRAS mutations have long been considered undruggable. However, a series of direct KRAS mutation inhibitors have been developed since the switch II pocket was discovered recently. This review will summarize progress in the development of direct KRAS G12C mutation inhibitors, current relevant drugs under study and challenges that need to be considered in future research.
CITATION STYLE
Yang, A., Li, M., & Fang, M. (2021, April 23). The Research Progress of Direct KRAS G12C Mutation Inhibitors. Pathology and Oncology Research. Frontiers Media S.A. https://doi.org/10.3389/pore.2021.631095
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