Sinapyl alcohol derivatives from the lipo-soluble part of Dichrocephala benthamii C. B. Clarke

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Abstract

Four new sinapyl alcohol derivatives dichrocephols A-D (compounds 1-4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 1-3 showed moderate cytotoxity against HeLa cells, with IC50 values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala. © 2013 by the authors.

Figures

  • Figure 1. Structures of compounds 1–5.
  • Figure 2. 1H–1H COSY, HMBC for compounds 1–4.
  • Figure 3. EIMS fragment ions of 2 and 4.
  • Table 1. 1H and 13C-NMR Spectroscopic Data for dichrocephols A–D (1–4).

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Tian, X., Ding, G., Peng, C., Hu, Y., Li, L., Chen, H., & Zou, Z. (2013). Sinapyl alcohol derivatives from the lipo-soluble part of Dichrocephala benthamii C. B. Clarke. Molecules, 18(2), 1720–1727. https://doi.org/10.3390/molecules18021720

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