Brain-Skin Connection: Impact of Psychological Stress on Skin

Abstract

The intricate relationship between stress and skin conditions has been documented since ancient times. Recent clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases. However, the exact underlying mechanisms have only been studied and partially revealed in the past 20 years or so, involving both the central and peripheral pathways. Psychological stress can play important roles in skin’s inflammation responses, barrier function, and wound healing. Long-term chronic stress can also lead to premature skin aging. In this chapter, the authors will discuss the recent discoveries in the field of “brain-skin connection,” summarizing findings from the overlapping fields of psychology, endocrinology, skin neurobiology, skin inflammation, immunology, and pharmacology.