Effects of Ascofuranone on the Mitochondria Isolated from Hansenula anomala

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Abstract

An antitumor antibiotic, ascofuranone, selectively inhibitedsuccinate- and NADPH-dependent 02 uptake activity of the mitochondria from Hansenula anomala, suggesting its interaction with the ubiquinone-reduction site of succinate dehydrogenase and external NADPH-dehydrogenase reactions. The action of ascofuranone on the mitochondria is clearly different from that of antimycin A, the Qi site inhibitor. Copyright © 1994, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.

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Minagawa, N., Meguro, K., Sakajo, S., & Yoshimoto, A. (1994). Effects of Ascofuranone on the Mitochondria Isolated from Hansenula anomala. Bioscience, Biotechnology, and Biochemistry, 58(7), 1334–1335. https://doi.org/10.1271/bbb.58.1334

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