Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.
CITATION STYLE
Song, Y., Chen, S., Liu, C., Chen, L., Wang, W., Wu, B., & Liang, Y. (2023). Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1051305
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