In this paper, a closed-loop system to regulate plasma osmolality in patients with central diabetes insipidus is investigated. Using model identification techniques, we obtained a 3 rd -order LTI model of the renal/body fluid system from an 11th-order nonlinear system. A Smith Predictor and an controller were developed. The effectiveness of the controller to reject a step disturbance in the plasma osmolality is examined. This paper shows the potential use of control theory in the context of central diabetes insipidus. © 2010 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Zaarouri, K., Haidar, A., & Boulet, B. (2010). Closed-loop control of plasma osmolality. In Advances in Intelligent and Soft Computing (Vol. 83, pp. 217–225). https://doi.org/10.1007/978-3-642-16259-6_17
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