Survival and disease complications in thalassemia major

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Abstract

We studied survival and disease complications in 1146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow-up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970-1974. Patients who died had a serum ferritin level, measured the year before death, significantly higher than those who survived. Diabetes was present in 5.4% of the patients; heart failure in 6.4%, arrhythmias in 5.0%, thrombosis in 1.1%, hypothyroidism in 11.6%, HIV infection in 1.8%. Hypogonadism was diagnosed in 55% of 578 patients who had reached pubertal age: 83.5% of hypogonadic females and 78.6% of males were receiving substitutive hormonal therapy. In conclusion, the survival of patients with thalassemia major is good and improving, but the prevalence of severe complications is still high.

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APA

Borgna-Pignatti, C., Rugolotto, S., De Stefano, P., Piga, A., Di Gregorio, F., Gamberini, M. R., … Verlato, G. (1998). Survival and disease complications in thalassemia major. In Annals of the New York Academy of Sciences (Vol. 850, pp. 227–231). Blackwell Publishing Inc. https://doi.org/10.1111/j.1749-6632.1998.tb10479.x

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