Abolishment of individual variation in effectiveness of Acupuncture Analgesia, Periaqueduct central gray Stimulation-Produced Analgesia and Morphine Analgesia

Abstract

in previous work from our labolatory, it was found that 1) morphine like factor(MLF) is involved in acupuncture and periaqueduct central gray (PAG) stimulation produced analgesia (SPA), 2) the individual variation in effectiveness of acupuncture analgesia fairly corresponed to that in contents of brain MLF and 3) the individual variation in effectiveness of acupuncture analgesia also fairly corresponed to that of PAG-SPA and of morphine analgesia. It is known that MLF includes several types of peptides, such as methionine and leucine enkephalins and a-, β-and γ-endorphins and that D-phenylalaine is a inhibitor of carboxypeptidase acting on above peptides. © 1979, Japan Society for Cell Biology. All rights reserved. © 1979, The Showa University Society. All rights reserved.