Modeling the spontaneous reaction of mammalian cells to external stimuli

Abstract

We argue that the potential benefits of developing highfidelity models of biological communication systems has enormous potential in terms of enhancing the understanding of biological systems and that such understanding is a major step towards detection and treatment of disease. By focusing on lysosomal enzyme response to stimuli, we demonstrate that the understanding of the protocols governing cellular communications is far from complete. We discuss some major challenges and outline promising approaches to reaching the next level. © Institute for Computer Sciences, Social Informatics and Telecommunications Engineering 2013.