Cranioencephalic functional lymphoid units in glioblastoma

3Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The ecosystem of brain tumors is considered immunosuppressed, but our current knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived from patients presenting with glioblastoma or nonmalignant intracranial disease to report that the cranial bone (CB) marrow, in juxtaposition to treatment-naive glioblastoma tumors, harbors active lymphoid populations at the time of initial diagnosis. Clinical and anatomical imaging, single-cell molecular and immune cell profiling and quantification of tumor reactivity identified CD8+ T cell clonotypes in the CB that were also found in the tumor. These were characterized by acute and durable antitumor response rooted in the entire T cell developmental spectrum. In contrast to distal bone marrow, the CB niche proximal to the tumor showed increased frequencies of tumor-reactive CD8+ effector types expressing the lymphoid egress marker S1PR1. In line with this, cranial enhancement of CXCR4 radiolabel may serve as a surrogate marker indicating focal association with improved progression-free survival. The data of this study advocate preservation and further exploitation of these cranioencephalic units for the clinical care of glioblastoma.

References Powered by Scopus

Integrated analysis of multimodal single-cell data

5959Citations
N/AReaders
Get full text

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

3820Citations
N/AReaders
Get full text

Fast, sensitive and accurate integration of single-cell data with Harmony

3451Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The conundrum of CD8<sup>+</sup> T cell trajectories in low antigenic tumors: How to overcome a hypofunctional state distinct from antigen-driven exhaustion?

0Citations
N/AReaders
Get full text

Skull bones harbour immune cells that are poised to target brain tumours

0Citations
N/AReaders
Get full text

Immune checkpoint inhibitors for glioblastoma: emerging science, clinical advances, and future directions

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Dobersalske, C., Rauschenbach, L., Hua, Y., Berliner, C., Steinbach, A., Grüneboom, A., … Scheffler, B. (2024). Cranioencephalic functional lymphoid units in glioblastoma. Nature Medicine. https://doi.org/10.1038/s41591-024-03152-x

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

52%

Researcher 6

29%

Professor / Associate Prof. 4

19%

Readers' Discipline

Tooltip

Neuroscience 7

35%

Medicine and Dentistry 6

30%

Biochemistry, Genetics and Molecular Bi... 5

25%

Immunology and Microbiology 2

10%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1
News Mentions: 11

Save time finding and organizing research with Mendeley

Sign up for free