Drug-drug interactions can represent a major public health issue. Drug metabolism science has evolved to the point where interactions with cytochrome P-450 isozymes can be predicted and potentially avoided or managed, but much work remains to allow accurate prediction of non-P-450 mediated interactions. Based on preclinical data, rational clinical plans can be developed to study potential drug-drug interactions in humans and develop labeling that allows optimal usage of new drugs. © 2011 American Association of Pharmaceutical Scientists.
CITATION STYLE
Hutzler, J. M., Cook, J., & Fleishaker, J. C. (2011). Drug-drug interactions: Designing development programs and appropriate product labeling. In Pharmacokinetics in Drug Development (Vol. 3, pp. 21–56). Springer US. https://doi.org/10.1007/978-1-4419-7937-7_2
Mendeley helps you to discover research relevant for your work.