Myocardial energetics and efficiency

Abstract

In addition to structural and functional abnormalities, it is well established that energy homeostasis is impaired in the failing heart. As the heart requires large amounts of energy to sustain its continuous pumping activity, it is highly dependent on an optimal substrate metabolism with efficient ATP generation and utilization. Alterations in processes related to energy production as well as energy utilization in the failing heart may lead to energetic imbalance, an inefficient hearts with impaired contractile reserve.