Six new pimprinine alkaloids (1–6), including four dimers, dipimprinines A–D (1–4), and two monomers, (±)-Pimprinol D (5), and pimprinone A (6), along with six known congeners (7–12), were isolated from a soil-derived actinomycete Streptomyces sp. NEAU-C99. Structures of the new compounds were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffractions, and ECD calculations. Dipimprinines A–D (1–4) showed weak cytotoxic activities against five tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values ranging from 12.7 to 30.7 μM.
CITATION STYLE
Yu, Z., Jiang, H., Wang, L., Yang, F. X., Huang, J. P., Liu, C., … Huang, S. X. (2020). Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99. Frontiers in Chemistry, 8. https://doi.org/10.3389/fchem.2020.00095
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