The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
CITATION STYLE
Thanasupawat, T., Glogowska, A., Burg, M., Wong, G. W., Hoang-Vu, C., Hombach-Klonisch, S., & Klonisch, T. (2015). RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer. Frontiers in Endocrinology, 6(JUL). https://doi.org/10.3389/fendo.2015.00127
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