Low biological activity of Helicobacter pylori lipopolysaccharide

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Abstract

Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.

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CITATION STYLE

APA

Muotiala, A., Helander, I. M., Pyhala, L., Kosunen, T. U., & Moran, A. P. (1992). Low biological activity of Helicobacter pylori lipopolysaccharide. Infection and Immunity. https://doi.org/10.1128/iai.60.4.1714-1716.1992

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