Chiral recognition mechanism: Practical considerations for pharmaceutical analysis of chiral compounds

Abstract

There are no particular differences between academic and industrial liquid chromatography chiral separations. In industry, throughput needs and time requirements force for a search for solutions, i.e., enantiomeric full separations, without time for additional investigations that could lead to an even better solution. The three-point interaction model is historically recalled and challenged. The established mechanisms on the large variety of commercially available chiral stationary phases are rapidly described. The chapter finishes with examples taken from actual enantiomeric separations encountered in a pharmaceutical environment. © 2010 Springer-Verlag Berlin Heidelberg.