THE ANTIFUNGAL EFFECT OF CRUD ALCOHOLIC EXTRACT OF ANCHUSA STRIGOSA ON T. PEDIS

Abstract

Tinea pedis is the most common type of fungal infection in human. The samples have been taken from fifty patients (26 female, 24 male) their ages ranged from 11 to over 60 years diagnosed as having Tinea pedis in Baghdad Teaching Hospital. All samples were examined directly after the addition of a drop of 10% KOH solution and then cultured on selective fungal culture media. The results showed that the rate of infection was more in females, and more in patients with age ranging from (30-39) years old, followed by those between (40-49) years old, and the causative fungi agents of fungal infection of T. pedis were mainly Trichophyton rubrum (72%) followed by Trichophyton mentagrophyte (32%) then Epidermophyton floccosum (12%) respectively. The inhibitory effect of alcoholic extract of Anchusa strigosa was tested in vitro on some causative fungi of Tenia pedis and the result were Compared with that of Antifungal Tolnaftate, and the result of it showed that Trichophyton mentagrophyte was affected by the extract more than Trichophyton rubrum and the percentage of growth inhibition by the extract for Trichophyton mentagrophyte at a concentration of (500) and (1000) P.P.M. were (65.11% and 100%) respectively, while that for Trichophyton rubrum were (53.68%, 87.36% and 100%) at a concentration of (500, 1000 and 1500) P.P.M. respectively. This extract was shown to be a promising antifungal agent in the future