Abstract
The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.
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CITATION STYLE
APA
Van Lanen, S. G. (2017). SAM cycles up for colibactin. Nature Chemical Biology, 13(10), 1059–1061. https://doi.org/10.1038/nchembio.2479
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