Next-generation humanized mice differentially support human HSPC maintenance and myelopoiesis. MISTRG mice support long-term human HSPC maintenance demonstrated by quaternary transplantation and development of human tissue macrophages.
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Sippel, T. R., Radtke, S., Olsen, T. M., Kiem, H.-P., & Rongvaux, A. (2019). Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models. Blood Advances, 3(3), 268–274. https://doi.org/10.1182/bloodadvances.2018023887