Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these translocations. However, in screening a panel of 20 MM cell lines, we identified six lines containing two genetically distinguishable c-myc alleles. For these six informative lines (and the corresponding tumor for one line) there is selective expression of one c-myc allele despite the apparent absence of translocation, DNA rearrangement, or amplification involving c-myc. This result suggests frequent tumor specific cis-dysregulation of c-myc in MM by a presently unknown mechanism.
CITATION STYLE
Kuehl, W. M., Brents, L. A., Chesi, M., Huppi, K., & Bergsagel, P. L. (1997). Dysregulation of c-myc in multiple myeloma. In Current Topics in Microbiology and Immunology (Vol. 224, pp. 279–282). Springer Verlag. https://doi.org/10.1007/978-3-642-60801-8_29
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