Cells die at different rates as a function of disease state, age, environmental exposure, and behavior [8, 10]. Knowing the rate at which cells die is a fundamental scientific question, with direct translational applicability. A quantifiable indication of cell death could facilitate disease diagnosis and prognosis, prioritize patients for admission into clinical trials, and improve evaluations of treatment efficacy and disease progression [1, 4, 14, 16]. Circulating cell-free DNA (cfDNA) in the bloodstream originates from dying cells and is a promising non-invasive biomarker for cell death.
CITATION STYLE
Caggiano, C., Celona, B., Garton, F., Mefford, J., Black, B., Lomen-Hoerth, C., … Zaitlen, N. (2020). Estimating the rate of cell type degeneration from epigenetic sequencing of cell-free dna. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 12074 LNBI, pp. 240–242). Springer. https://doi.org/10.1007/978-3-030-45257-5_21
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