Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors are contributing to its development. Innate immunity may have a great influence in autoimmunity through Toll-like receptors. TLR-7 recognizing single-strand RNA has been involved in SLE. Its activation induces intracellular signal with attraction of MyD88 and NF-kBp65, leading to INF-α synthesis which correlate with disease activity. Objective: To assess the expression of TLR-7, MyD88, and NF-kBp65 in B lymphocytes of Mayan women with SLE. Methods: One hundred patients with SLE and 100 healthy controls, all of them Mayan women, were included. TLR-7 was analyzed on B and T lymphocytes, and MyD88 and NF-kB only in B lymphocytes. Serum INF-α level was evaluated by ELISA. Results: Significant expression (p < 0.0001) of TLR-7 in B and T lymphocytes and serum INF-α increased (p = 0.034) was observed in patients. MyD88 and NF-kBp65 were also increased in B lymphocytes of patients. TLR-7 and NF-kBp65 expression correlated, but no correlation with INF-α and disease activity was detected. Conclusion: Data support the role of TLR-7 and signal proteins in the pathogenesis of SLE in the Mayan population of Yucatán.
CITATION STYLE
Pacheco, G. V., Novelo Noh, I. B., Velasco Cárdenas, R. M. H., Angulo Ramírez, A. V., López Villanueva, R. F., Quintal Ortiz, I. G., … Rivero Cárdenas, N. A. (2016). Expression of TLR-7, MyD88, NF-kB, and INF-α in B lymphocytes of mayan women with systemic lupus erythematosus in Mexico. Frontiers in Immunology, 7(FEB). https://doi.org/10.3389/fimmu.2016.00022
Mendeley helps you to discover research relevant for your work.