Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application.
CITATION STYLE
Sieber, J., Renner, S., Lakatos-Krepcik, A., & Szépfalusi, Z. (2021). Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years. Frontiers in Pediatrics, 9. https://doi.org/10.3389/fped.2021.663228
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