Abstract
New 2-(2,4-dihalogenophenyl)-1-(1H-imidazol-1-yl)-3-(isoxazol-5-yl) propan-2-ols and 2-(2,4-dihalogenophenyl)-1-(1H-imidazol-1-yl)-3- (4,5-dihydroisoxazol-5-yl)propan-2-ols were synthesized by 1,3-dipolar cycloaddition between homopropargylic or homoallylic alcohols and in-situ generated nitrile oxide. Their antifungal activity was evaluated against Candida albicans, C. glabrata, Aspergillus fumigatus and an azole- resistant petite mutant of C. glabrata. Preliminary SAR results are discussed.
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Chevreuil, F., Landreau, A., Séraphin, D., Larcher, G., Mallet, S., Bouchara, J. P., & Richomme, P. (2007). Synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 22(5), 563–569. https://doi.org/10.1080/14756360701425279
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