Preparation of Biosensor Based on Supermolecular Recognization

Abstract

Supermolecular chemistry, also known as “chemistry beyond the molecule, " is an emerging interdisciplinary research, which focuses on the study of complex and ordered assemblies formed by noncovalent interactions, such as metal coordination, hydrogen bonding, p-p stacking, van der Waals force, and hydrophobic interaction [1, 2]. As an important research content in supermolecular chemistry, host-guest molecular recognization refers to the process in which a receptor molecule (host) specifically binds with a ligand molecule (guest) through noncovalent interactions and subsequently produces a certain function. The electronic properties and geometry structures of host molecules play an extremely significant role in host-guest recognization. The former enables the interactions between various molecules to obtain effective utilization, and the latter helps to match their geometric configurations with molecular sizes. The unique properties of supermolecular recognization hold great promise for practical applications in a wide variety of technological fields, such as sensing analysis, molecular imaging, metal extraction, and drug delivery [3-7].