Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells. Recent studies have revealed that interleukin-15 also plays a critical role in cancer immunotherapy. Interleukin-15 agonist molecules have shown that interleukin-15 agonists are effective in inhibiting tumor growth and preventing metastasis, and some are undergoing clinical trials. In this review, we will summarize the recent progress in interleukin-15 research over the past 5 years, highlighting its potential applications in cancer immunotherapy and the progress of interleukin-15 agonist development.
CITATION STYLE
Cai, M., Huang, X., Huang, X., Ju, D., Zhu, Y. Z., & Ye, L. (2023). Research progress of interleukin-15 in cancer immunotherapy. Frontiers in Pharmacology. Frontiers Media S.A. https://doi.org/10.3389/fphar.2023.1184703
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